Effects of imatinib mesylate on spontaneous electrical and mechanical activity in smooth muscle of the guinea‐pig stomach
H Hashitani, M Hayase, H Suzuki - British journal of …, 2008 - Wiley Online Library
Background and purpose: Effects of imatinib mesylate, a Kit receptor tyrosine kinase
inhibitor, on spontaneous activity of interstitial cells of Cajal (ICC) and smooth muscles in the
stomach were investigated. Experimental approach: Effects of imatinib on spontaneous
electrical and mechanical activity were investigated by measuring changes in the membrane
potential and tension recorded from smooth muscles of the guinea‐pig stomach. Its effects
on spontaneous changes in intracellular concentration of Ca2+ ([Ca2+] i)(Ca2+ transients) …
inhibitor, on spontaneous activity of interstitial cells of Cajal (ICC) and smooth muscles in the
stomach were investigated. Experimental approach: Effects of imatinib on spontaneous
electrical and mechanical activity were investigated by measuring changes in the membrane
potential and tension recorded from smooth muscles of the guinea‐pig stomach. Its effects
on spontaneous changes in intracellular concentration of Ca2+ ([Ca2+] i)(Ca2+ transients) …
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